The .22-250 Remington cartridge is available in a variety of bullet weights, ranging from 35 to 80 grains, giving shooters a wide range of options to choose from. The lighter bullets are typically used for varmint hunting, where a high velocity and flat trajectory are needed to take down small and fast-moving targets. The heavier bullets are more suited for larger game, such as coyotes and foxes, as well as long-range target shooting.

One of the potential downsides of the .22-250 Remington cartridge is its tendency to cause excessive meat damage when used for hunting. The high velocity of the bullet can cause the bullet to fragment and break apart upon impact, leading to significant damage to the animal's meat. For this reason, some hunters may choose to use a heavier bullet or a different cartridge altogether when hunting for meat. However, for those who prioritize accuracy and effectiveness in varmint hunting and long-range target shooting, the .22-250 Remington cartridge remains a popular and effective choice.